Interstate 280 (I-280) is a 12.41-mile-long highway that connects I-75 in northeast Toledo, Ohio with I-80/I-90 (part of the Ohio Turnpike) southeast of the city in northeastern Wood County, Ohio.

As of June 25, 2007, the Veterans' Glass City Skyway was opened, replacing the Craig Memorial Bridge, thus taking I-280 off the short list of drawbridges in the Interstate Highway system. After the Glass City Skyway opened, the Craig Bridge was reconstructed, and it now carries State Route 65 (SR 65).

The southern end of I-280 is an interchange in Wood County with exit  71 along the Ohio Turnpike's (I-80/I-90). South of this interchange, the I-280 freeway transitions to SR 420, a divided highway without access control, that also provides access to a truck stop and other businesses. Continuing north, I-280 runs through farm land and through an interchange with Bahnsen Road, which also provides access to other motorist- and trucking-related businesses. North of the SR 795 interchange, the freeway turns to the northwest. At the Wellbridge Road interchange in Walbridge, Ohio, I-280 turns back due north. On either side of the Interstate, the surroundings transition from farms to residential subdivisions. I-280 crosses the rail line used by the Capitol Limited and Lake Shore Limited passenger train routes operated by Amtrak. North of this crossing, the freeway passes into Lucas County.

I-280 turns northwesterly again in the city of Oregon. This area is suburban residential neighborhoods as the freeway approaches the Maumee River. The Interstate crosses the river on the Veterans' Glass City Skyway, an 8,800-foot (2,700 m), cable-stayed bridge. On the opposite bank of the river, I-280 turns northward and passes through an intersection with SR 25. There is one final interchange with I-75 where I-280 terminates.