Interstate 480 (I-480) is a loop highway that connects the Ohio Turnpike (I-80) with suburban Cleveland, Ohio. The highway is officially designated the Outerbelt South Freeway, but it is rarely referred to by that name.

The western terminus is at I-80 in North Ridgeville while the eastern terminus is at I-80 in Streetsboro. The width varies from four to ten lanes. The entire length of I-480 is 41.77 miles (67.22 km). I-480 provides access to Cleveland Hopkins International Airport via Ohio State Route 237.

The freeway is concurrent with I-271 for two miles. I-271 and I-480 are the only two three-digit interstates in the nation that run concurrently with each other for any distance. They run concurrent near Bedford Heights in Cuyahoga County. In Greensboro, North Carolina, future I-785 will run concurrently with I-840.[citation needed]

In 1998, the Governor of Ohio, George Voinovich, gave I-480 the additional name of the "Senator John Glenn Highway", in honor of the former NASA astronaut and a U.S. Senator from Ohio for 24 years.

The Valley View Bridge, which is 212 feet (65 m) high and spans 4,150 feet (1,260 m), carries I-480 across the Cuyahoga River valley.

Parts of I-480 were to have been I-271 and/or Interstate 80N.

The portion of freeway connecting I-480 to I-271 and US 422 is called Interstate 480N, an Ohio Department of Transportation designation. It is rarely referred by this name.