Interstate 490 (I-490) is a 2.43-mile (3.91 km) Interstate Highway in Cleveland, Ohio. The western terminus is a junction with I-90 and I-71 on Cleveland's west side. After spanning the Cuyahoga River, the eastern terminus is a junction with East 55th Street, just east of I-77.

In 2008, the Ohio Department of Transportation closed I-90 to trucks over the Innerbelt Bridge due to weight concerns. Trucks traveling eastbound are detoured onto I-490 east, then exit at I-77 north and rejoin I-90 east at I-77's northern terminus. Traveling westbound, trucks exit I-90 west at I-77 south, then exit at I-490 west before rejoining I-90 at I-490's western terminus.

The original plans of the Cleveland and other city and federal highway authorities called for the highway – also known as the Clark Freeway and, at various times and in various sections, as Interstate 80N and Interstate 290 – to bisect the east side of the city and the eastern suburbs; the I-290 designation would have continued north along I-271. A referendum in Shaker Heights in the late 1960s, however, barred the city from allowing the highway to pass through the city and its Shaker Lakes. This put a large and impassable hole in the plans and made the completion of the highway as a whole impossible. A segment at the western end opened in 1990 as I-490.

The interchanges between I-490 and West 7th Street and between I-90 and West 14th Street/Abbey Avenue were designed to complete the missing movements at the stack interchange at what is now the termini of both I-71 and I-490; I-71 was to continue along the Innerbelt to Dead Man's Curve (in addition to the original Clark Freeway plans), while I-290 was to have used a portion of present I-90 meet the Parma Freeway. After the freeway revolts killed the Clark Freeway east of East 55th Street and the Parma Freeway, I-90 was realigned to follow the Innerbelt and part of I-290.

In April 2011, the ramps between I-77 and I-90 to the west were removed, making I-490 the official route between those highways and between I-77 and I-71.

There have been subsequent proposals to employ part of the I-290 routing. The current plan, part of the Innerbelt project, proposes an expressway to University Circle, named the "Opportunity Corridor". After temporary rejections in 2002 and 2006 – the latter due to Secretary of State Ken Blackwell's loss in the 2006 gubernatorial campaign after he had reintroduced the plan as part of a plan to lease the Ohio Turnpike – the plan is active again. In June 2008, the start date for the project was planned to be 2015, earlier than the 2025 or later date previously planned. In 2009, a plan to incorporate the highway as a toll road was proposed. That same year, a director of the project was named, and the Opportunity Corridor Steering Committee was formed, holding its first meeting on May 15. As of July 2011 the earliest date of construction is 2016, providing that funding is available.

The entire route is in Cleveland, Cuyahoga County.