U.S. Route 68 is an east–west United States highway that runs for 560 miles (900 km) from northwest Ohio to western Kentucky. The highway's western terminus is at U.S. Route 62 in Reidland, Kentucky. Its eastern terminus is at Interstate 75 in Findlay, Ohio. It is signed east–west in Kentucky and north–south in Ohio

US 68 is designated as a "Scenic Highway" throughout Kentucky. The majority of the route winds through forested, hilly terrain.

US 68 passes several Civil war battle sites. The Battle of Tebbs Bend Historic Civil War Site is located near Campbellsville and the Perryville Battlefield State Historic Site is outside Perryville.

US 68 hosts an annual 400-Mile yard sale for 4 days in early summer.

US 68 through Campbellsville and Lebanon is slated for expansion to begin in 2008. The long-term goal is to widen and make safer the entire US 68 corridor through Kentucky as part of the Heartland Parkway project,

Sections in Kentucky have been improved in recent years. The Paris Pike which was completed in 2003. Work is currently in progress to make US 68 four lanes through Land Between the lakes.

Two spans of the US 68/KY 80 Eggner Ferry Bridge over Kentucky Lake collapsed after being struck by a cargo ship on January 26, 2012. The bridge reopened to traffic on May 25, 2012.

U.S. 68 takes a north–south route throughout much of Ohio. For much of the route, it roughly parallels Interstate 75 as it runs south from its junction with said interstate to the Kentucky Border. As US 68 proceeds southward from Findlay, it generally lies one county east of Interstate 75. The route is an important connector for cities and villages in western Ohio. It also is used as the Springfield, Ohio bypass.