U.S. Route 169 (also known as Mingo Valley Expressway and Pearl Harbor Memorial Expressway in the Tulsa Area) is a U.S. highway that begins in Tulsa southwest of Downtown. The highway runs north into Kansas.

U.S. 169 begins at an interchange with U.S. 64 in Tulsa. This interchange also marks the beginning of a free segment of the Creek Turnpike; continuing west beyond the terminus of US-169 without exiting onto US-64 will incur a toll. US-64 westbound joins US-169 northbound in a concurrency as the two highways head east. US-64/US-169 then bear to the north as the Creek Turnpike splits away to the east and resumes tolling. The two routes pass through southeast Tulsa on a due north course, following the Mingo Valley Expressway, a freeway. Upon reaching the Broken Arrow Expressway (State Highway 51), US-64 splits off toward downtown Tulsa, while US-169 continues north through east Tulsa. The next interchange US-169 has with another freeway is with I-44; 1.8 miles (2.9 km) to the north of this, it interchanges with I-244. As it continues north, US-169 serves as the western terminus of SH-266. The freeway crosses Bird Creek on a pair of 1960-vintage through truss bridges seven miles (11 km) north of I-44.

US-169 then enters the north Tulsa suburb of Owasso. Here, the freeway's interchange with 2nd Avenue also forms the eastern terminus of SH-135, an unsigned highway. The freeway continues on towards Collinsville, where it has a concurrency with SH-20. North of Collinsville, the freeway ends, and US-169 continues northeast as an at-grade highway. The highway briefly crosses into Rogers County, then re-enters Tulsa County, before returning to Rogers County once again.

In Rogers County, US-169 heads northeast until it reaches the town of Oologah, birthplace of Will Rogers, where it serves as the western terminus for SH-88. South of the town, US-169 crosses Fourmile Creek, a tributary of the Verdigris River; the route will parallel this creek until its source as the road continues north. The highway also runs parallel to a rail line for the remainder of its time in Oklahoma, and several miles to the east, it also parallels the shoreline of Oologah Lake. As the highway passes through northern Rogers County, the highway bisects the town of Talala.

Soon after US-169 crosses from Rogers County to Nowata County, the highway passes through the unincorporated location of Watova, Oklahoma. The route then enters the county seat, Nowata. US-169 Alternate follows the old route of US-169 through downtown Nowata, while mainline US-169 cuts through the eastern side of town. Both branches of US-169 intersect with US-60 in Nowata. On the north end of town, the alternate route reunites with the mainline, and US-169 continues north. North of Nowata, the highway passes to the west of Nowata Municipal Airport, then crosses California Creek, an tributary of the Verdigris. Southeast of Delaware, US-169 meets SH-28 at its western terminus. As US-169 continues north, it passes to the east of Delaware and Lenapah. East of Lenapah, it begins a concurrency with SH-10, which lasts for 4 + 1⁄2 miles (7.2 km) before SH-10 splits off to the west. US-169 continues north through unincorporated Elliott, then enters the border town of South Coffeyville. In South Coffeyville, the highway crosses the state line into Montgomery County, Kansas; it continues north to Coffeyville.

US-169 was first designated through Oklahoma on June 17, 1935. Prior to the establishment of US-169, the route north of Collinsville was served by State Highway 16; US-169 replaced this route in its entirety.