Interstate 410 (abbreviated I-410, and colloquially called Loop 410) is a loop route of Interstate 10 around San Antonio, Texas. It is identified as Connally Loop in honor of former Texas governor John Connally. The north and west section is undergoing a major expansion from six to ten lanes (five in each direction) from Culebra Road to the I-35 interchange as well as major interchanges being renovated at Bandera Road, I-10 and San Pedro Avenue, and an interchange recently constructed at US 281 near San Antonio International Airport.

Interstate 410 circumnavigates the city of San Antonio, officially beginning and ending at the junction with Interstate 35 on the southwest side of the loop. There are vast differences between the northern arc and southern arc of the loop. The northern arc serves the heavily urbanized portions of San Antonio and is currently being upgraded to as many as five lanes in each direction. The southern arc resembles more of a rural interstate as it transverses for the most part undeveloped portions of San Antonio as a two lane interstate. I-410 intersects I-10 twice, I-35 twice, I-37 once, as well as U.S. Highway 90, US 281, and State Highway 151, all freeways in the San Antonio metro area with the exception of 1604, which forms a secondary loop around the city. I-410 serves San Antonio International Airport, Lackland AFB, Fort Sam Houston, South Texas Medical Center, Southwest Research Institute, and Toyota Motor Manufacturing Texas.

Like most cities in Texas, San Antonio was served by a loop around the city long before the arrival of the Interstate Highway System. Loop 13, although not a freeway, served in this role up until the 1950s, when many of San Antonio's freeways were constructed. The northern half of Loop 13 followed the current path of I-410 while the southern half still exists on the south side of San Antonio. Much of the freeway was proposed during the mid-1950s with construction beginning on the northwest portion of the loop near I-10. In 1960, Loop 13 from I-10 to I-35 was redesignated as Loop 410 for continuity purposes. By 1961 the freeway had been completed from I-35 on the southwest side to just east of US 281 near the airport where it continued on to the east as a 4-lane highway to I-35. By 1964 the southern arc had been extended eastward from I-35 to Roosevelt Avenue and was under construction from Roosevelt to I-35 on the east side of the city. By 1967 the eastern arc had been completed to Interstate Highway standards and the remaining portion from US 281 to I-35 on the cities north side had been completely upgraded to Interstate Highway standards, but still carried the State Loop 410 designation until 1969 when it officially became Interstate 410.

Due to the city growing primarily to the north, I-410 required upgrading along this stretch. It was expanded to six lanes in the late 1970s and early 1980s from Ingram Road to I-35 North. It was further expanded to six lanes from Ingram to Valley Hi Road in 1987. An additional westbound lane was added from I-10 West to Babcock Road in 1996.

I-410 was widened from the late 1990s through early 2010s along its entire northern arc from Culebra road to Austin Highway, with five lanes each way and intersection upgrades at I-10 and San Pedro, and an entire new interchange at US 281, officially called the "San Antonio Web".

Exit numbers correspond to mileage from the south junction with I-35. The entire highway is in Bexar County.