State Highway 41 is a state highway that runs through the Texas Hill Country in Kerr, Real, and Edwards Counties.

SH 41 was proposed in 1919 as a route from Del Rio to Rocksprings to Kerrville to Boerne. By 1933, the highway had been shortened at both ends, now starting north of Del Rio and ending at Mountain Home. In 1951, the western section was transferred to U.S. Highway 377, shortening the route to its present length.