U.S. Route 183 (US 183) is a north-south U.S. highway that begins in Texas in Refugio at an intersection with US 77 concurrent with US 77 ALT. The highway runs through many small comunities with Austin being the only major city along its route. The highway exits Texas concurrent with US 70, crossing into Oklahoma.

US 183 begins in Refugio at an intersection with US 77. US 77 ALT also begins at this intersection. The two highways travel north towards the historic town of Goliad. A few miles north of Cuero, US 77 ALT leaves the highway.

US 183 travels through many towns, including Gonzales and Luling before reaching Lockhart. Just north of Lockhart, the highway interchanges with the SH 130 toll road, and begins an "overlap" with the highway. US 183 becomes the frontage road for the toll road until Mustang Ridge, where SH 130 joins the SH 45 toll road.

Upon entering Austin, US 183 has many interchanges before becoming a freeway, just south of US 290. This freeway lasts until the 183A toll road. While 183A serves as a bypass around Cedar Park and Leander, US 183 serves as a more direct surface street.

Leaving the Austin area, 183 reaches Lampasas, where it overlaps US 190 and US 281. In Goldthwaite, the highway overlaps SH 16 and US 84. Just outside of Brownsville, the overlap with US 84 ends. Hwy 183 crosses I-20 just south of Cisco. South of Throckmorton, US 283 joins the highway, an overlap that lasts until Vernon, where 183 joins US 70 and US 287. In Oklaunion, US 70 and 183 leave US 287 and cross the Red River together into Oklahoma.