U.S. Route 277 is a north–south United States Highway. It is a spur of U.S. Route 77. It runs for 633 miles (1,019 km) across Oklahoma and Texas. US 277's northern terminus is in Newcastle, Oklahoma at Interstate 44, which is also the northern terminus of the H.E. Bailey Turnpike. Its southern terminus is in Carrizo Springs, Texas at U.S. Route 83. It passes through the states of Oklahoma and Texas.

Most of U.S. 277's route through the two states overlaps other U.S. highways. Those include U.S. 62 from Newcastle to Chickasha, Oklahoma, U.S. 62 and U.S. 281 from five miles (8 km) west of Elgin, Oklahoma to Lawton, U.S. 281 from Lawton to Wichita Falls, Texas, U.S. 82 from Wichita Falls to Seymour, Texas, and U.S. 83 from Anson, Texas to Abilene, Texas. Through the Lawton area and again from Randlett, Oklahoma to near downtown Wichita Falls, U.S. 277 is also co-signed with I-44.

When U.S. 277 was commissioned in 1930, it ended at the U.S.-Mexico border in Del Rio, Texas. It was extended southeast to its present terminus in 1952. The original northern terminus was in Oklahoma City at its intersection with parent route U.S. 77 and U.S. 62. The northern terminus remained there until 1964. when it was truncated to its present terminus following the completion of the H.E. Bailey Turnpike and the connecting U.S. 62 freeway into Oklahoma City, which would become Interstate 44 in the 1980s. As of February 2010, U.S. 277 allows a speed limit of 75 mph only in Dimmit County, Texas.