US 221 (FL) Travel Info
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U.S. Route 221 (US 221) in Florida is a north–south United States Highway. It runs 40 miles (64 km) from Perry northwest to the Georgia State Line in Taylor, Madison and Jefferson Counties. The entire route contains the hidden State Road 55. Two concurrencies exist along the road, both of which are in the Greenville area. The first is with Madison County Ro ... more
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